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By Joseph C. Arcos, Yin-Tak Woo, Mary F. Argus

Chemical Induction of melanoma: Structural Bases and organic Mechanisms quantity IIIA offers with the natural and biochemical rules in the back of cancer.

This quantity comprises the continuation of quantity IIA, which tackles structure-activity relationships of chemical cancer causing agents, the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic job. lower than this can be non-conjugated natural compounds.

The textual content is usually recommended for medical professionals, natural chemists, and biochemists with a sophisticated wisdom in biochemistry and natural chemistry and wish to understand extra the biochemical approaches of melanoma.

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An extensive study of the inhalation toxicity of bis(chloromethyl) ether and chloromethyl methyl ether has been re­ cently carried out by Drew et al. (97) in Sprague-Dawley rats and Syrian golden hamsters. The most characteristic acute toxic effect of both compounds was the irritation of the respiratory tract manifested by congestion, edema, and hemor­ rhage (mainly of the lungs), and acute necrotizing bronchitis. Multiple exposures of animals to subacutely toxic concentrations of either compound resulted in severe shortening of lifespan and a variety of regenerative, hyperplastic, and metaplastic alterations of trachea and bronchi.

5/1000/yr 8. 48/1000/yr 5/136/18 yr 4. 59/1000/yr 0. 5 4 / 1 3 6 / 1 8 y r 0. 5 7 / 1 0 0 / 5 y r 0. 0 2 4 / 3 2 / 1 6 y r C a n c e r i n c i d e n c e in c o n t r o l g r o u p (Y ) 3. 96 208 Increased risk (X/Y) Increased Risk of Respiratory Cancers after Exposure to Bis(chloromethyl) Ether and/or Chloromethyl Methyl Ether Table XVIII < 0. 01 - - - - < 0. 0017 < 0. 1 Direct-Acting Carcinogens | 45 much lower than was previously anticipated (96). This has significantly ex­ panded the potential site of bis(chloromethyl) ether exposure to any place where high atmospheric levels of hydrochloric acid and formaldehyde may coexist.

Its half-life in aqueous solution cannot be directly measured with accuracy. Jones and Thornton (91) have measured the hydrolysis rate of chloromethyl methyl ether in aqueous isopropanol. Extrapolation of the data to pure water yielded a tll2 of less than 1 sec (92). In aqueous methanol at 45°C, the hydrolysis rate of chloromethyl methyl ether was about 5000 times faster than that of bis(chloromethyl) ether (93). In contrast to a-chloro compounds, the jS-chloro compounds are much more stable. 1 Carcinogenic Cross-Linking Agents and Alkyl Donors Table XI Structural Formulas of Haloethers Which Have Been Tested for Carcinogenicity Compound Chloromethyl methyl ether (CMME) Formula ClCH 2 OCH 3 Bis-(chloromethyl) ether (BCME) ClCH 2 OCH 2 Cl d, (y-Dichloromethyl methyl ether Cl 2 CHOCH 3 Bis -(α-chloroethyl) ether CH 3 CH(Cl)OCH(Cl)CH 3 B i s - O - c h l o r o e t h y l ether (BCEE) ClCH 2 CH 2 OCH 2 CH 2 Cl Bis (j3-chloroisopropyl) ether (BCIE) ClCH 2 CH(CH a )OCH(CH 3 )CH 2 Cl Bis-(£-chloro->'-trichloro-ji-propyl) ether [Octachlorodi-ri-propyl e t h e r ] Cl 3 CCH(Cl)CH 2 OCH 2 CH(Cl)CCl a Cl 2, 3-Dichlorotetrahydrofuran Cl Cl 2, 3 - t r a n s - Dichloro-p-dioxane Cl B i s - 1 , 2-(chloromethoxy) ethane C1CH 2 0(CH 2 ) 2 0CH 2 C1 B i s - 1 , 4-(chloromethoxy) butane C1CH20(CH2)4OCH20 B i s - 1 , 6-(chloromethoxy) hexane C1CH 2 0(CH 2 ) 6 0CH 2 C1 B i s - 1 , 4-(chloromethoxy) £-xylene ClCH 2 OCH 2 C 6 H 4 CH 2 QCH 2 Cl T r i s - 1 , 2, 3-(chloromethoxy) propane CH ?

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