Download Acute and Long-Term Side-Effects of Radiotherapy: Biological by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. PDF

By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)

Biologists and radiotherapists current their experimental paintings and medical facts within the box of radiation accidents of ordinary tissues and organs. specific regard is payed to the relevance of organic mechanisms in scientific events. rules of radiation harm and mixed remedy toxicity in radio-chemotherapy are being defined. the most issues mentioned are the significance of microvasculature, time, doseand fractionation and components enhancing medical radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and dermis, lung and middle, bladder and muscle, CNS and eye. unique difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.

Show description

Read Online or Download Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance PDF

Best clinical books

Handbook Attitudes and Attitude Change

Attitudes-cognitive representations of our overview of ourselves, other folks, issues, activities, occasions, ideas-and perspective switch were a relevant main issue in social psychology because the self-discipline all started. humans can-and do-have attitudes on an enormous diversity of items yet what are attitudes, how can we shape them and the way can they be transformed?

Clinical Blood Pool MR Imaging: The Vasovist® Product Monograph

"This very good treatise on Vasovist® created by means of a group of outstanding school who're pioneers in MR Angiography covers the fundamental innovations, safeguard, efficacy, photograph processing and pharmaco-economic info to effectively enforce a brand new point of MRA snapshot caliber with this new distinction agent. " Martin Prince, Cornell collage, ny "The editors and authors have made groundbreaking contributions in the direction of setting up MR angiography in a variety of investigative settings, rendering it extra designated and using it for various symptoms.

Anasthesie in Frage und Antwort: Basic Sciences. Clinical Sciences

Das moderne Konzept dieses Arbeitsbuches erlaubt eine bedarfsorientierte duale Anwendung. Zum einen kann durch die Beantwortung der gestellten Fragen das eigene Wissen quantifiziert werden. Der verwendete Fragentyp und das Bewertungssystem sind identisch mit demjenigen, das von der Europäischen Akademie für Anästhesiologie (EAA) eingesetzt wird, so daß speziell auch die Vorbereitung auf die EAA-Prüfung erleichtert wird.

Extra resources for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance

Sample text

5 could be an artifact of the specialized procedure (with the DMIPS) used to measure cell survival, since dose-related changes were not seen in the neutron response. Therefore, at the same high level of cell survival, X-ray and neutron doses were similar. 5 \ 0 \ \ ~.... u.. 2 \ 0 1 \ 2 3 Dose (Gy) 4 5 Fig. 5. Typical experiment using V79 hamster cells in vitro irradiated with single doses of X-rays or neutrons. 6Gy, the dose-survival relationship conforms to a conventional LQ model. 6Gy, the LQ model substantially underpredicts the effect of X-rays.

1984). In a third organ, the kidney, a similar effect was seen, namely a differential recovery of colony-forming efficiency after neutrons or X-rays (Jen and Hendry 1993). The differential was also found for the time factor (during fractionation) for functional injury in the pig kidney (Robbins et al. 1991a). Hence three organ systems show a similar pattern of differential recovery after X-rays or neutrons using various endpoints. Regarding repopulation and LET, no significant differences have been noted in the rate of appearance and disappearance of skin reactions in rodents or in humans, or in survival times of rodents irradiated with LD50/3o doses of X-rays or neutrons (data reviewed by Hendry 1972).

I "0 >- ~ I "! 40 X (ii '0 20 ~ ? 1 (Gy) Fig. 4a,b. Total dose to the mouse lung needed for an increase in breathing rate by 20% compared with controls in half the subjects measured at 28 weeks (EDso, a) or total dose needed for mortality in half the subjects (LDso, b) at 44-48 weeks. ). Errors are SEM, within the data points if not shown. Although not significant in these studies, there is a trend towards a greater effect of low-dose X-ray fractionation compared with the LQ model. (Data from Parkins et al.

Download PDF sample

Rated 4.77 of 5 – based on 49 votes